Lysosomes, autophagosomes and Alzheimer pathology in dementia with Lewy body disease
نویسندگان
چکیده
منابع مشابه
Alzheimer and Lewy body pathology or Creutzfeldt-Jakob disease.
The objective of this work is to describe the neuropathological findings of a patient clinically presenting with rapidly progressive nonspecific neurological symptoms suggestive of Creutzfeldt-Jakob disease. Methods used were clinical description with laboratory analyses, repeated electroencephalogram, cerebral computed tomography, magnetic resonance imaging studies and details on neuropatholog...
متن کاملLewy body disease and dementia with Lewy bodies
In 1976 we reported our first autopsied case with diffuse Lewy body disease (DLBD), the term of which we proposed in 1984. We also proposed the term "Lewy body disease" (LBD) in 1980. Subsequently, we classified LBD into three types according to the distribution pattern of Lewy bodies: a brain stem type, a transitional type and a diffuse type. Later, we added the cerebral type. As we have propo...
متن کاملGBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology.
OBJECTIVES Mutations in the GBA gene occur in 7% of patients with Parkinson disease (PD) and are a well-established susceptibility factor for PD, which is characterized by Lewy body disease (LBD) neuropathologic changes (LBDNCs). We sought to determine whether GBA influences risk of dementia with LBDNCs, Alzheimer disease (AD) neuropathologic changes (ADNCs), or both. METHODS We screened the ...
متن کاملContribution of Lewy body inclusions to dementia in patients with and without Alzheimer disease neuropathological conditions.
CONTEXT Lewy bodies (LBs) are intraneuronal inclusions in the brain that have been increasingly recognized as neuropathological lesions with relevance not only to Parkinson disease but also to Alzheimer disease. However, the degree to which the density of LBs in the brain contributes to the severity of dementia has not been clear. OBJECTIVE To determine the degree to which LB "burden" contrib...
متن کاملLewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype.
BACKGROUND The origin and significance of Lewy bodies and neurites (Lewy body pathology [LBP]) in Alzheimer disease (AD) are poorly understood. OBJECTIVE To examine LBP in the brainstem, limbic cortex, and neocortex of a large number of familial AD cases with mutations in 2 presenilin (PSEN) genes. METHODS Twenty-five familial AD cases with 9 known PSEN 1 mutations and 14 familial AD cases ...
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ژورنال
عنوان ژورنال: Neuropathology
سال: 2018
ISSN: 0919-6544
DOI: 10.1111/neup.12472